Advance Intermediates

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Intermediates

Saving you time and cost with our selection of high-quality intermediates
Flavine under­stands the chal­leng­ing needs of API man­u­fac­tur­ers and offers an expen­sive pipeline of advance inter­me­di­ates that save pro­duc­tion cost and time. Our inter­me­di­ates are cru­cial pre­cur­sors to many com­mon API prod­ucts sold in the US and EU mar­kets. We also pro­vide cus­tom syn­the­sis of unique inter­me­di­ates and chem­i­cal compounds.

Our advance intermediates provide swift routes to key chemical classes:

  • Antibi­otics
  • Com­plex Small Molecules
  • Cor­ti­cos­teroids
  • Macro­cy­cles
  • Nat­ur­al Products
  • Nucleotides and Derivatives 
  • Oligonu­cleotides
  • Oligosac­cha­rides
  • Organometallics
  • Pep­tides
  • Steroids
  • Vit­a­mins

Click here to download Intermediate Commercial Product List:

Go to Inter­me­di­ates Com­mer­cial list

Click here to download Intermediates Under Development Product List:

Go to Inter­me­di­ates Under Devel­op­ment List

Intermediate Commercial Product List

INTERMEDIATE
CHEMICAL NAME		STRUCTURECAS NUMBERFINAL TARGET
ACTIVE INGREDIENT		STRUCTURE
Dehy­droepiandros­terone53–43‑0Abi­raterone
Ade­nine73–24‑5 Ade­nine, ATP
Adeno­sine58–61‑7Adeno­sine
Aza­ery­thromycin amine76801–85‑9Azithromycin
3-(4‑Chlorphenyl)glutaric acid amide1141–23‑7Baclofen
5‑Amino-2-Cyanoben­zotri­flu­o­ride654–70‑6Bica­lu­tamide
2-[[4-[[2-(1‑methylethoxy)ethoxy]methyl]phenoxy]methyl] oxi­rane66722–57‑4Biso­pro­lol
1-(2‑Pyrimidinyl)piperazine20980–22‑7Bus­pirone
3,3‑Tetramethyleneglutarimide1075–89‑4Bus­pirone
1,1‑Cyclobutane dicar­boxylic acid5445–51‑2Car­bo­platin
4‑Amino-5-imi­da­zole­car­box­am­ide hydrochloride72–40‑2Dacar­bazine
2-(2‑Hydroxyphenyl)-4H‑1,3‑benzoxazin-4-one1218–69‑5Deferasirox
1-[(2,3‑Dihydro‑1,4‑benzodioxin-2-yl)-carbonyl]-piperazine70918–00‑2Dox­a­zosin mesylate
Dehy­droepiandros­terone53–43‑0Drospirenone
3β,5β-Dihydroxy-15β,16β-methylene-6-androsten-17-one82543–15‑5Drospirenone
3β,5‑Dihydroxy-6β,7β,15β,16β-dimethylene-5β-androstan-17-one82543–16‑6Drospirenone
Estrone53–16‑7Estetrol (E4)
19-Noran­drostene­dione734–32‑7Cor­ti­cos­teroid derivatives
∆5‑Norandrostenedione 3962–66‑1Cor­ti­cos­teroid derivatives
20α-hydroxymethylpregna‑1,4‑diene-3-one35525–27‑0Cor­ti­cos­teroid derivatives
Dimepra­nol Acedoben61990–51‑0Ino­sine Pranobex
1‑Phe­noxy-2-iso­propy­lamine35205–54‑0Isox­suprine
3,5‑Diiodo-L-Thyronine1041–01‑6Levothy­rox­ine Sodium
Ery­thromycin114–07‑8 MacrolidesN/A
Ery­thromycin Thiocyanate7704–67‑8MacrolidesN/A
Methyl Aminoben­zoyl Glutaminester 2378–95‑2Methotrex­ate
Mycophe­no­lic acid 24280–93‑1Mycophe­no­late Mofetil 
6-(4‑benzylamino-3-nitrophenyl)-5-methyl-2H-pyridazin-3-one77469–62‑6Pimoben­dan
6‑Methoxy-2-(4‑methoxyphenyl)-benzo[b] thio­phene63675–74‑1Ralox­ifene
(S)-3–1‑Dimethylamino Eth­yl Phenol 139306–10‑8Rivastig­mine
Sodi­um Nitro­prus­side crude13755–38‑9Sodi­um Nitroprusside
(S)-3-tert-Butylamino‑1,2‑propanediol30315–46‑9Tim­o­lol
3‑Chloro-4-morpholino‑1,2,5‑thiadiazole30165–96‑9Tim­o­lol
4‑Chloropy­ri­dine-3-sul­fon­amide33263–43‑3Torasemide
1-(3‑Chlorophenyl)-4-(3‑chloropropyl)-piperazine hydrochlo­ride52605–52‑4Tra­zodone
1-(3‑Chlorophenyl)-piperazine hydrochlo­ride65369–76‑8Tra­zodone
1,2,4‑Triazolo[4,3‑a]pyridin‑3(2H)-one6969–71‑7Tra­zodone
9(10)-Dehydronandrolone6218–29‑7Tren­bolone

Intermediate Under Development Product List

INTERMEDIATE
CHEMICAL NAME		STRUCTURECAS NUMBERFINAL TARGET
ACTIVE INGREDIENT		STRUCTURE
1-(2‑Amino-1-[(4‑methoxy-2-(phenylethyl)]-cyclohexanol93413–77‑5Ven­lafax­ine
1,4‑Benzodioxan-2-carboxylic acid3663–80‑7Dox­a­zosin
1-[(4‑Isopropoxy)-ethoxymethyl]-hydroxybenzene177034–57‑0Biso­pro­lol
1-[2-(2‑Hydroxyethoxy)ethyl]piperazine13349–82‑1• Dixyrazine
• Que­ti­ap­ine fumarate 		Mul­ti­ple API targets
1-[4-(acetyloxy)-3,5‑dimethoxyphenyl]-2-Bromoethanone 28294–48‑6Dimetofrine
10-OH-camp­tothecin 7689–03‑4  Camp­tothecin
1‑Ben­zyl-4-cyano-4-phenylpiperi­dine hydrochloride71258–18‑9Pir­itramide
1‑Chloro‑6,6‑Dimethyl-2-Hepten-4-Yne 126764–17‑8Terbinafine
1H-ben­z­im­i­da­zole- 7‑carboxylic acid 2‑ethoxy-1-[(2’-(1H-tetrazol-5-yl)-1,1’-biphenyl ‑4-yl)methyl]-ethyl ester139481–58‑6Can­desar­tan
1‑methyl-2-(7‑methyl-2-propyl-1H-benzo [d]imidazole-5-yl)-1H-benzo[d]imidazole 152628–02‑9Telmis­ar­tan
1-[(2′-Cyano‑1,1′-biphenyl-4-yl)methyl]-2-ethoxy-7-benzimidazolecarboxylic Acid Methyl Ester139481–44‑0Can­desar­tan
2 Ethoxy 1 2” Cyano 1 1” Biphenyl 4 yl Methyl 1H valeroyl-Ben­z­im­i­da­zole 7 Car­boxylic acid Eth­yl Ester139481–41‑7Can­desar­tan
2-(4‑methoxy benzylamino)-pyridine52818–63‑0Pyril­amine
2-(Dimethylamino)-ethanethiol hydrochlo­ride13242–44‑9Echoth­io­phate iodide
2,4,5,6‑Tetraaminopyrimidine sul­fate5392–28‑9• 2,4,5,6‑Tetrachloropyrimidine
• Lumazine
• Methotrexate		Mul­ti­ple API targets
2,4‑Dichloro-5-sulfamoylbenzoic acid2736–23‑4Furosemide
2,6‑Diaminopurine1904–98‑9• (2S-cis)-5-(6‑Amino-2-fluoro- 9H-purin-9-yl)-tetrahydro-2-furanmethanol
• Fludarabine
• Flu­dara­bine phosphate		Mul­ti­ple API targets
2,7‑Dichoro-α-[(dibutylamino)methyl]- 9 H fluorine-4-methanol 69759–61‑1Lume­fantrine
2-[(Dimethylamino)-methyl]-cyclo hexa­none hydrochloride42036–65‑7• Tra­madol
• Tra­madol hydrochloride
2-[4-[(methylsulfonyl)oxy]phenyl]-Benzo[b] thio­phene-6-ol 6‑methanesulfonate 84449–65‑0• Nitron­aprox­en
• Raloxifene		Mul­ti­ple API targets
2‑Chlorotriphenylchloromethane42074–68‑0Clotri­ma­zole
2‑Diethylaminoethanethiol100–38‑9• Dal­fo­pristin
• Fencarbamide
• Thiphenamil hydrochloride		Mul­ti­ple API targets
2‑ethoxy-1-[(2’-(1‑trityl-1H-tetrazol-5-yl)-1,1’-biphenyl-4-yl)methyl]- 7- ben­z­im­i­da­zole­car­boxylic acid139481–72‑4Can­desar­tan
2‑Phenoxy Eth­yl Chloride622–86‑6• Bephe­ni­um 3‑hy­droxy-2-naph­thoate
• Idoxifene		Mul­ti­ple API targets
2‑Pyrrolidinoethyl chlo­ride hydrochloride7250–67‑1• Centchro­man
• Histapyrrodine		Mul­ti­ple API targets
3-(1‑Piperazinyl)-1,2‑benzisothiazole hydrochlo­ride87691–88‑1• Ziprasi­done
• Ziprasi­done hydrochloride
3-(4‑Chlorophenyl)-glutaric acid1189874–68‑7Baclofen
3-(4‑Chlorophenyl)-glutaric anhy­dride53911–68‑5Baclofen
3,11-dichloro‑6,11-dihydro-6-methyldibenzo [c,f] [1,2] thi­azepine 5,5 dioxide26638–66‑4Tianep­tine Sodium
3,4‑Dihydroxy Ben­zoni­trile17345–61‑8Pro­to­cat­e­chuoni­trile
3-[5-(Fluorophenyl)-1,5‑dioxopentyl]- 4(S)-phenyl-2-oxazolidinone189028–93‑1Eze­tim­ibe
3‑Chloro‑6,11-dihydro-6-methyl‑5,5,11- tri­ox­odiben­zo [c,f][1,2]thiazepine26638–53‑9Tianep­tine Sodium
4-(2‑Aminoethyl)-benzenesulfonamide35303–76‑5• Glimepiri­de
• Glipizide
• Gliquidone
• Glisentide
• Glisolamide
• Glisoxepid
• Glyburide		Mul­ti­ple API targets
4-(2‑Piperidinoethoxy)-benzoic acid hydrochloride84449–80‑9Ralox­ifene
4-(3‑Methyl-phenyl)amino-3-pyridine sul­fon­amide72811–73‑5Torsemide
4-(((4‑Fluorophenyl)imino)methyl)phenol3382–63‑6Eze­tim­ibe
4-(4‑Chlorophenyl)-4-piperidinol39512–49‑7• Haloperi­dol
• Loperamide
• Lop­eramide hydrochloride
• Lop­eramide oxide		Mul­ti­ple API targets
4-(4‑Chlorophenyl)-glutarimide84803–46‑3Baclofen
4-(4‑Fluorobenzoyl)-butyric acid149437–76‑3Eze­tim­ibe
4-[2-(5‑Chloro-2-methoxybenzamido)- ethyl]-phenyl sulfonamide16673–34‑0Gly­buride
4-[4-(Dimethylamino)-1-(4‑fluorophenyl)-1- (hydroxybutyl)-3-(hydroxymethyl) benzonitrile103146–25‑4Citalo­pram
4‑Aminopyridine504–24‑5• 4-(Dimethylamino)-pyridine
• Indibulin
• Lexipafant
• Milverine
• Octeni­dine hydrochloride
• Oglemilast
• Pinacidil
• Roflumilast
• Sulfadoxine		Mul­ti­ple API targets
4‑Chloro-3-sul­famoyl­ben­zoic acid1205–30‑7• Clopamide
• Tripamide		Mul­ti­ple API targets
4‑Chloro-5-sul­famoyl­sal­i­cylic acid14556–98‑0Xipamide
4‑Hy­droxy-3-pyridi­ne­sul­fon­ic acid51498–37‑4Torsemide
4‑Hydroxybenzophenone1137–42‑4• Clomiphene
• Tamoxifen
• Toremifene		Mul­ti­ple API targets
5‑Amino-2-nitroben­zotri­flu­o­ride393–11‑3• Fluridil
• Flutamide
• Nilutamide		Mul­ti­ple API targets
5‑Bromophthalide64169–34‑2• Citalo­pram
• Citalo­pram hydrobromide		Mul­ti­ple API targets
5‑Chloro-o-anisic acid 3438–16‑2Gly­buride
5‑Chloro-o-anisic acid methyl ester33924–48‑0Gly­buride
5‑Cyanophthalide82104–74‑3• Citalo­pram
• Escitalopram		Mul­ti­ple API targets
5′-O-Trityl‑2,3′-anhydrothymidine5964–41‑0Zidovu­dine
6‑Amino-2-chloropy­ri­dine45644–21‑1N-(2‑Chloro-4-pyridinyl)-N’-phenylurea
6‑Hydroxy-2-(4‑hydroxyphenyl) ben­zo (b) thiophene 63676–22‑2Ralox­ifene
7‑Aminoheptanoic acid hydrochloride 62643–56‑5• Aminep­tine
• Aminep­tine hydrochloride
• Tianep­tine Sodium		Mul­ti­ple API targets
7‑Aminoheptanonic Acid eth­yl ester hydrochloride29840–65‑1Tianep­tine Sodium
Anisil1226–42‑2• Flu­mi­zole
• Idanpramine		Mul­ti­ple API targets
Bis-(2‑chloroethyl)-amine hydrochlo­ride821–48‑7• 1-(4‑Methoxyphenyl)-piperazine
• Cyclophosphamide
• Estra­mus­tine phosphate
• Itraconazole
• Ketoconazole
• N‑Phenylpiperazine		Mul­ti­ple API targets
Ethyl‑1,4‑benzodioxane-2-carboxylate4739–94‑0Dox­a­zosin
Glu­tar­ic anhydride108–55‑4Granisetron
Glu­tar­ic acid110–94‑1• 2,6‑Diaminopyridine
• Gus­per­imus trihydrochloride		Mul­ti­ple API targets
Hydro­cor­ti­sone50–23‑7Cor­ti­cos­teroidsN/A
Methyl 2,3‑dibromopropionate1729–67‑5Dox­a­zosin
Methyl 2,3‑dihydro‑1,4‑benzodioxine-2-carboxylate3663–79‑4Dox­a­zosin
Methyl-4-methyl biphenyl-2-car­boxy­late114772–34‑8Telmis­ar­tan
N-(2‑Chloroethyl)-diethylamine hydrochlo­ride869–24‑9• 5-(Diethylamino)-2-pentanone
• Amiodarone
• Butethamate
• Butoxy­caine hydrochloride
• Camylofine
• Caroverine
• Chloroquine
• Chromonar
• Diet­hazine hydrochloride
• Diethy­laminoethyl cellulose
• Doxylamine
• Flurazepam
• Lucanthone
• Nafronyl
• Tiropramide		Mul­ti­ple API targets
N-(2‑Chloroethyl)-diisopropylamine hydrochlo­ride4261–68‑1• Diiso­promine
• Disopyramide
• Iso­propamide iodide		Mul­ti­ple API targets
N-(2‑Chloroethyl)-dimethylamine hydrochlo­ride4584–46‑7• 1-(2‑Dimethylaminoethyl)-5-mercaptotetrazole
• Bephe­ni­um 3‑hy­droxy-2-naph­thoate
• Brompheniramine
• Carbinoxamine
• Chloropyramine
• Chlorpheniramine
• Chlorphenoxamine
• Diben­zepin hydrochloride
• Dimethindene
• Doxylamine
• Meclofenoxate
• Pheni­ramine maleate
• Phenyltoloxamine
• Pyrilamine
• Tibezo­ni­um iodide
• Tripelennamine		Mul­ti­ple API targets
N-(2‑Chloroethyl)-morpholine hydrochlo­ride3647–69‑6Flo­redil
N-(2‑Chloroethyl)-piperidine hydrochlo­ride2008–75‑5Ralox­ifene
N-(2‑Chloropropyl)-dimethyl amine hydrochloride4584–49‑0• Isoth­ipendyl hydrochloride
• Methadone		Mul­ti­ple API targets
N-(2‑Furoyl)-piperazine40172–95‑0• Pra­zosin
• Pra­zosin hydrochloride
• Terazosin		Mul­ti­ple API targets
N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline 70627–52‑0Eze­tim­ibe
N-(2′-Cyanobiphenyl-4-ylmethyl)-L-valine methyl ester137863–89‑9Val­sar­tan
N-(2′-Cyanobiphenyl-4-ylmethyl)-N-pentanoyl-L-valine ben­zyl esterN/AVal­sar­tan
N-[4-[2-(3‑ethyl-4-methyl-2-oxo-3-pyrroline-1-carboximido) eth­yl Ben­zene sulphonamide119018–29‑0Glimepiri­de
Sodi­um butyrate156–54‑7• Iophe­nox­ic acid
• Sodi­um butyrate		Mul­ti­ple API targets
Thiomor­pho­line123–90‑0Sute­zol­id
Tianep­tine Acid66981–73‑5 Tianep­tine Sodium

For infor­ma­tion about inter­me­di­ates prod­uct avail­abil­i­ty and devel­op­ment sta­tus please con­tact us.

Europe Con­tact Information

FLAVINE EUROPE GMBH

Wehrlestrasse 12
81679 Munich, Ger­many
Phone: [+49] 89–939-967–0
Fax: [+49] 89–939-967–16
E‑Mail: Flavine-europe@flavine.eu

Get in Touch

For infor­ma­tion about inter­me­di­ates prod­uct avail­abil­i­ty and devel­op­ment sta­tus please con­tact us.

North Amer­i­ca Con­tact Information

FLAVINE NORTH AMERICA INC

61 South Para­mus Road, Suite 565
Para­mus, NJ 07652, USA
Phone: [+1] 201–768-4190
Fax: [+1] 201–768-2854
E‑Mail: sales@flavine.com

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Disclaimers:

Some of the prod­ucts list­ed are cur­rent­ly under devel­op­ment and there­fore per­ti­nent infor­ma­tion may not be avail­able at this time. Any prod­uct list­ed which is cov­ered under cur­rent patents is avail­able only for use rea­son­ably relat­ed to the devel­op­ment and sub­mis­sion of infor­ma­tion to the rel­e­vant Health Author­i­ties to the extent per­mit­ted under applic­a­ble laws reg­u­lat­ing the man­u­fac­ture, use and sale of Active Phar­ma­ceu­ti­cal Ingre­di­ents, and/or their intermediates.